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Functions and applications of metallic and metallic oxide nanoparticles in orthopedic implants and scaffolds

材料科学 金属 纳米技术 生物医学工程 骨科手术 纳米颗粒 氧化物 复合材料 医学 外科 冶金
作者
Niyou Wang,J.Y.H. Fuh,S. Thameem Dheen,A. Senthil Kumar
出处
期刊:Journal of Biomedical Materials Research Part B [Wiley]
卷期号:109 (2): 160-179 被引量:62
标识
DOI:10.1002/jbm.b.34688
摘要

Abstract Bone defects and diseases are devastating, and can lead to severe functional deficits or even permanent disability. Nevertheless, orthopedic implants and scaffolds can facilitate the growth of incipient bone and help us to treat bone defects and diseases. Currently, a wide range of biomaterials with distinct biocompatibility, biodegradability, porosity, and mechanical strength is used in bone‐related research. However, most orthopedic implants and scaffolds have certain limitations and diverse complications, such as limited corrosion resistance, low cell proliferation, and bacterial adhesion. With recent advancements in materials science and nanotechnology, metallic and metallic oxide nanoparticles have become the subject of significant interest as they offer an ample variety of options to resolve the existing problems in the orthopedic industry. More importantly, these nanoparticles possess unique physicochemical and mechanical properties not found in conventional materials, and can be incorporated into orthopedic implants and scaffolds to enhance their antimicrobial ability, bioactive molecular delivery, mechanical strength, osteointegration, and cell labeling and imaging. However, many metallic and metallic oxide nanoparticles can also be toxic to nearby cells and tissues. This review article will discuss the applications and functions of metallic and metallic oxide nanoparticles in orthopedic implants and bone tissue engineering.
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