特瑞氟米特
医学
多发性硬化
奥图穆马
单克隆抗体
CD20
药理学
皮肤病科
抗体
免疫学
芬戈莫德
作者
Stephen L. Hauser,Amit Bar‐Or,Jeffrey Cohen,Gıancarlo Comı,Jorge Correale,Patricia K. Coyle,Anne H. Cross,de Sèze,David Leppert,Xavier Montalbán,Krzysztof Selmaj,Heinz Wiendl,Cécile Kerloëguen,Roman Willi,Bingbing Li,Algirdas Kakarieka,Davorka Tomic,Alexandra Goodyear,Ratnakar Pingili,Dieter A. Häring
标识
DOI：10.1056/nejmoa1917246
摘要
Ofatumumab, a subcutaneous anti-CD20 monoclonal antibody, selectively depletes B cells. Teriflunomide, an oral inhibitor of pyrimidine synthesis, reduces T-cell and B-cell activation. The relative effects of these two drugs in patients with multiple sclerosis are not known.
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