坏死性下垂
免疫原性
光热治疗
免疫疗法
免疫原性细胞死亡
癌症研究
佐剂
免疫系统
癌细胞
癌症
程序性细胞死亡
细胞凋亡
癌症免疫疗法
材料科学
化学
医学
免疫学
纳米技术
生物化学
内科学
作者
Henan Zhao,Haolin Chen,Zhouyi Guo,Wen Zhang,Hongfeng Yu,Zhengfei Zhuang,Huiqing Zhong,Zhiming Liu
标识
DOI:10.1016/j.cej.2020.124314
摘要
Photo-immunotherapy taking advantages of the immunogenic cell death (ICD) induced by photothermal therapy (PTT) to facilitate the systemic anti-tumor immunity has been exploited as a promising therapeutic approach for cancer. However, this kind of in situ tumor vaccine is of less efficacy due to the anisotropic immunogenicity profiles of dying cells after PTT. Herein, a facile strategy is proposed to activate the necroptosis, a programmed cell death with intense immunogenicity, in photothermal ablated cells by easily modulating the PTT parameters, which enables the optimal ICD for anti-tumor immunity. As an emerging 2D nanomaterial, black phosphorus (BP) serves as the near-infrared (NIR)-responsive nanoagent to trigger PTT. Necroptosis in ablated tumor cells is confirmed by the high expression of key proteins in necroptotic pathway. The necroptotic cells also exhibit considerable immunogenicity by the release of damage-associated molecular patterns to potentiate the immune responses. Further an immunologic adjuvant is grafted onto the BP nanosheets and the high-performance cancer photo-immunotherapy is achieved. This easy-to-access photo-immunotherapeutic strategy by in situ photothermal activation of necroptosis supplies new insights in the treatment of cancer.
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