Modulome-Fangjiome Association Study (MoFAS) reveals differential target distribution among four similar fangjis (formulas)

医学 传统医学 人工智能 计算机科学
作者
Pengqian Wang,Weiwei Zhou,Jun Liu,Feng Sui,Zhong Wang
出处
期刊:Journal of Ethnopharmacology [Elsevier]
卷期号:279: 113822-113822 被引量:3
标识
DOI:10.1016/j.jep.2021.113822
摘要

Precise target distribution is a key issue for further appropriate applications of fangjis (formulas) with similar efficacy and herbal constituents to maximize efficacy and minimize toxicity.To develop an algorithm for investigating the differential target distributions and characteristic mechanisms of fangjis.In this study, we proposed a Modulome-Fangjiome Association Study (MoFAS) for comparing fangjis from qi-invigorating and xue-nourishing fangjiome (represented by four fangjis: FEJ, SDT, LYG and QOL). Firstly, the database-driven target network of these 4 fangjis was constructed as qi-xue network and decomposed into modules. Then, the modular map with functional landscape were constructed based on consistency score and enrichment analysis. Finally, we employed a targeting rate (TR) matrix to assess the contribution of this fangjiome to modulome (a set of modules) and compared characteristic effect of fangjis by principal component analysis (PCA).A qi-xue network constituted by 579 proteins and 23 modules were constructed. In the functional landscape, 3 primary modules were mainly involved in the endocrine system and environmental adaptation. For the target distribution, SDT and QOL were more similar; the FEJ and LYG were located distant from other fangjis according to PCA. The common effects of FEJ, SDT, and QOL focused on stress response and organism development in environmental perturbation, but the FEJ was superior in regulating critical targets, primarily focusing on hormone and neurotransmitter processes. SDT and QOL were concentrated on the majority scale of the qi-xue network, especially for the mitotic cell cycle and development. LYG only targeted lymphocyte costimulation and icosanoid biosynthetic processes.In this study, for the first time, we investigated the difference in the target distribution of qi-invigorating and xue-nourishing fangjiome and provided direct evidence for the characteristic therapeutic effect of these fangjis, which may promote the precise application of fangjis and support the identification of appropriate populations.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
liu bo完成签到,获得积分10
刚刚
1秒前
1秒前
隐形荟完成签到 ,获得积分10
1秒前
沙珠完成签到,获得积分10
1秒前
共享精神应助Hui_2023采纳,获得10
2秒前
2秒前
杨文磊完成签到,获得积分10
2秒前
蒜命师完成签到,获得积分10
2秒前
百合子完成签到,获得积分10
2秒前
羡鱼完成签到,获得积分10
2秒前
西米完成签到 ,获得积分10
3秒前
Owen应助清脆的又蓝采纳,获得10
3秒前
Jasper应助xinC采纳,获得10
4秒前
张倩完成签到,获得积分10
5秒前
谬伤完成签到,获得积分10
6秒前
MY20240406完成签到,获得积分10
7秒前
不穷知识完成签到,获得积分10
7秒前
7秒前
无奈世立完成签到,获得积分10
7秒前
Joshua完成签到,获得积分10
7秒前
陈雷应助迷路曼青采纳,获得10
7秒前
smallfish发布了新的文献求助30
7秒前
hehe发布了新的文献求助10
8秒前
Leon_nomoreLess完成签到 ,获得积分10
8秒前
Peyton Why完成签到,获得积分10
9秒前
可爱的函函应助小小采纳,获得10
9秒前
李子木完成签到,获得积分20
9秒前
10秒前
小丸子完成签到 ,获得积分10
10秒前
69发布了新的文献求助10
10秒前
星河完成签到,获得积分10
10秒前
10秒前
托物言宇发布了新的文献求助10
10秒前
ZZZ发布了新的文献求助10
11秒前
FashionBoy应助123采纳,获得10
11秒前
12秒前
12秒前
qhy完成签到,获得积分10
12秒前
科研醉汉完成签到,获得积分10
12秒前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
Pharmacogenomics: Applications to Patient Care, Third Edition 800
Gerard de Lairesse : an artist between stage and studio 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3081744
求助须知:如何正确求助?哪些是违规求助? 2734831
关于积分的说明 7534536
捐赠科研通 2384276
什么是DOI,文献DOI怎么找? 1264252
科研通“疑难数据库(出版商)”最低求助积分说明 612606
版权声明 597600