已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Modulome-Fangjiome Association Study (MoFAS) reveals differential target distribution among four similar fangjis (formulas)

医学 传统医学 人工智能 计算机科学
作者
Pengqian Wang,Weiwei Zhou,Jun Liu,Feng Sui,Zhong Wang
出处
期刊:Journal of Ethnopharmacology [Elsevier BV]
卷期号:279: 113822-113822 被引量:3
标识
DOI:10.1016/j.jep.2021.113822
摘要

Precise target distribution is a key issue for further appropriate applications of fangjis (formulas) with similar efficacy and herbal constituents to maximize efficacy and minimize toxicity.To develop an algorithm for investigating the differential target distributions and characteristic mechanisms of fangjis.In this study, we proposed a Modulome-Fangjiome Association Study (MoFAS) for comparing fangjis from qi-invigorating and xue-nourishing fangjiome (represented by four fangjis: FEJ, SDT, LYG and QOL). Firstly, the database-driven target network of these 4 fangjis was constructed as qi-xue network and decomposed into modules. Then, the modular map with functional landscape were constructed based on consistency score and enrichment analysis. Finally, we employed a targeting rate (TR) matrix to assess the contribution of this fangjiome to modulome (a set of modules) and compared characteristic effect of fangjis by principal component analysis (PCA).A qi-xue network constituted by 579 proteins and 23 modules were constructed. In the functional landscape, 3 primary modules were mainly involved in the endocrine system and environmental adaptation. For the target distribution, SDT and QOL were more similar; the FEJ and LYG were located distant from other fangjis according to PCA. The common effects of FEJ, SDT, and QOL focused on stress response and organism development in environmental perturbation, but the FEJ was superior in regulating critical targets, primarily focusing on hormone and neurotransmitter processes. SDT and QOL were concentrated on the majority scale of the qi-xue network, especially for the mitotic cell cycle and development. LYG only targeted lymphocyte costimulation and icosanoid biosynthetic processes.In this study, for the first time, we investigated the difference in the target distribution of qi-invigorating and xue-nourishing fangjiome and provided direct evidence for the characteristic therapeutic effect of these fangjis, which may promote the precise application of fangjis and support the identification of appropriate populations.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
YuLu完成签到 ,获得积分10
刚刚
Jiayi完成签到 ,获得积分10
1秒前
Strike完成签到,获得积分10
1秒前
Emma完成签到,获得积分10
1秒前
Salt发布了新的文献求助10
2秒前
苗条青槐完成签到 ,获得积分10
3秒前
Strike发布了新的文献求助30
4秒前
zhaoxi完成签到 ,获得积分10
4秒前
七月完成签到,获得积分10
5秒前
morena发布了新的文献求助200
6秒前
眼睛大的胡萝卜完成签到 ,获得积分10
7秒前
盐先生完成签到 ,获得积分10
11秒前
太叔丹翠完成签到 ,获得积分10
12秒前
12秒前
14秒前
15秒前
香蕉觅云应助Dz1990m采纳,获得10
15秒前
龙弟弟完成签到 ,获得积分10
16秒前
婷婷完成签到,获得积分10
19秒前
21秒前
光能使者完成签到,获得积分10
23秒前
26秒前
26秒前
清风明月完成签到 ,获得积分10
27秒前
Sophiaye完成签到,获得积分10
28秒前
只想发财发布了新的文献求助10
28秒前
芯之痕发布了新的文献求助10
29秒前
xiuxiuzhang完成签到 ,获得积分10
29秒前
排骨大王完成签到,获得积分10
30秒前
32秒前
LILING发布了新的文献求助10
33秒前
菲菲酱完成签到 ,获得积分10
34秒前
39秒前
jin发布了新的文献求助10
40秒前
隐形曼青应助大恶魔宝拉采纳,获得30
42秒前
WindDreamer完成签到,获得积分10
43秒前
是述不是沭完成签到,获得积分10
44秒前
落落完成签到 ,获得积分0
45秒前
45秒前
风清扬应助现代期待采纳,获得30
46秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976572
求助须知:如何正确求助?哪些是违规求助? 3520659
关于积分的说明 11204365
捐赠科研通 3257284
什么是DOI,文献DOI怎么找? 1798667
邀请新用户注册赠送积分活动 877835
科研通“疑难数据库(出版商)”最低求助积分说明 806577