医学
放射治疗
多元分析
单变量分析
胶质瘤
内科学
肿瘤科
生存分析
单变量
比例危险模型
存活率
总体生存率
外科
危险系数
间变性星形细胞瘤
脑瘤
回顾性队列研究
多元统计
癌症研究
统计
数学
作者
Jaspar Witteler,Troels W. Kjær,Soeren Tvilsted,Steven E. Schild,Dirk Rades
出处
期刊:Anticancer Research
[Anticancer Research USA Inc.]
日期:2020-10-27
卷期号:40 (11): 6513-6515
被引量:1
标识
DOI:10.21873/anticanres.14674
摘要
Background/Aim: Previously, we identified predictors of survival after irradiation of grade II-IV cerebral gliomas. In this supplementary analysis, survival was calculated in a more appropriate way than the original study. Patients and Methods: Ten factors were re-evaluated for survival in patients of the original study including pre-radiotherapy seizures. In the original study, survival was calculated from the end of the last radiotherapy course (primary or re-irradiation). After re-review, this approach was considered inappropriate. Survival should have always been calculated from the first radiotherapy course, as done in this supplementary analysis. Results: On multivariate analysis, WHO-grade II (p=0.006) and upfront resection (p=0.001) were associated with better survival. Unifocal glioma was significant on univariate analysis (p=0.001), where a trend could be identified for age ≤59 years (p=0.057) and seizures (p=0.060). Conclusion: The findings of this supplementary analysis regarding the identification of prognostic factors for survival agree with the results of the original study.
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