红色毛癣菌
孟加拉玫瑰
毛癣菌
光动力疗法
微生物学
孢子
皮肤病科
生物
医学
抗真菌
化学
遗传学
有机化学
作者
Jessica Houang,Catriona Halliday,Sharon Chia-Ju Chen,Chun-Hoong Ho,Alina M. Bekmukhametova,Antonio Lauto
标识
DOI:10.1002/jbio.202000340
摘要
Abstract Photodynamic therapy (PDT) with Rose Bengal has previously achieved eradication of Trichophyton rubrum infections causing toenail onychomycosis; however, its antifungal activity against other clinically relevant dermatophytes has yet to be studied. Here, we test the efficacy of PDT using Rose Bengal (140 μM) and 532 nm irradiation (101 J/cm 2 ) against Trichophyton mentagrophytes and Trichophyton interdigitale spores, in comparison to T. rubrum . A significant reduction (>99%) of T. mentagrophytes and T. interdigitale was observed, while actual eradication of viable T. rubrum was achieved (99.99%). Laser irradiation alone inhibited growth of T. rubrum (55.2%) and T. mentagrophytes (45.2%) significantly more than T. interdigitale (25.5%) ( P = .0086), which may indicate an increased presence of fungal pigments, xanthomegnin and melanin. The findings suggest that Rose Bengal‐PDT can act against a broader spectrum of fungal pathogens, and with continued development may be employed in a wider range of clinical antifungal applications.
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