Sodium-glucose transport protein 2 inhibitors and risk of incident stroke: A systematic review and meta-analysis

Background and Aims: Although experimental studies have suggested a potential neuroprotective effect of sodium-glucose contransporter-2 (SGLT2) inhibitors, human trials have demonstrated controversial results regarding their effect on the risk of stroke. In this context, we evaluated published evidence regarding the effect of treatment with SGLT2 inhibitors on the risk of ischemic stroke.