[A concise review of telomere and telomerase-related genetic markers in fibrotic lung diseases].

Fibrotic lung diseases are a heterogeneous group of diffuse parenchymal lung diseases caused by various factors. Pulmonary fibrosis is one of the common pathological changes of advanced fibrotic lung diseases. Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disorder with unknown etiology. IPF mainly affects the elderly that is considered as an aging related disease. Telomeres are specialized structures at the ends of chromosomes. Telomere shortening results in cellular senescence or apoptosis. Telomerase is a ribonucleoprotein complex that maintains telomere length and genome stability. The telomere shortening and mutations in telomere-related genes are associated with incidence and prognosis of pulmonary fibrosis. Here, a concise review of telomere and telomerase-related genomic markers in IPF and other fibrotic lung diseases is written.纤维化性肺疾病是一组由多种原因引起的异质性弥漫性肺疾病，肺纤维化是终末期纤维化性肺疾病共同的病理改变之一。特发性肺纤维化（IPF）是一种代表性的纤维化性肺疾病，多见于中老年人，其发病与衰老相关。端粒是细胞染色体末端的帽状结构，端粒长度缩短时，细胞会发生衰老或凋亡。端粒酶是维持端粒长度、遗传稳定性的核糖核蛋白复合物。细胞端粒长度缩短和端粒酶基因突变与纤维化性肺疾病发病及预后有关。我们旨在综述端粒、端粒酶相关基因标志物与IPF及其他纤维化性肺疾病的研究进展。.