Auto–Cross-Linked Hyaluronic Acid Gel for Prevention of Intrauterine Adhesions after Hysteroscopic Adhesiolysis: A Randomized Controlled Trial

医学 宫腔镜检查 随机对照试验 四分位间距 宫内节育器 外科 妇科 计划生育 人口 环境卫生 研究方法
作者
Qiaoyun Zhou,Xiaoyu Shi,Sotirios H. Saravelos,Xiaowu Huang,Yuting Zhao,Rui Huang,Enlan Xia,Tin Chiu Li
出处
期刊:Journal of Minimally Invasive Gynecology [Elsevier BV]
卷期号:28 (2): 307-313 被引量:48
标识
DOI:10.1016/j.jmig.2020.06.030
摘要

ABSTRACT

Study Objective

To investigate auto–cross-linked hyaluronic acid gel for the prevention of intrauterine adhesion (IUA) recurrence after hysteroscopic adhesiolysis.

Design

A single-center, double-blinded randomized controlled trial.

Setting

A tertiary university hospital.

Patients

Two hundred seventy-two patients with moderate-to-severe (American Fertility Society [AFS] score ≥5) IUAs underwent hysteroscopic adhesiolysis.

Interventions

The patients were randomized to receive standard care along with auto–cross-linked hyaluronic acid gel after surgery (treatment group) or standard care only (control group). All patients had second-look hysteroscopy at 4 weeks and hormonal therapy for 2 cycles after surgery.

Measurements and Main Results

Two hundred sixty patients were eligible and randomized; 245 patients successfully completed the study (n = 122 in treatment group, and n = 123 in control group). The primary outcome measure was IUA recurrence at second-look hysteroscopy. The secondary outcome measures included an improvement in the AFS score and menstrual pattern. There was no significant difference with regard to IUA recurrence (31.1% vs 39.8%) or median AFS score at second-look hysteroscopy (2, interquartile range [2–4] vs 2, interquartile range [2–4]) or improvement in the menstrual pattern at 3-month follow-up (87.7% vs 76.4%), in the treatment and control groups, respectively.

Conclusion

The application of auto–cross-linked hyaluronic acid gel did not seem to improve IUA recurrence after hysteroscopic adhesiolysis.
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