去细胞化
表征(材料科学)
细胞外基质
材料科学
制作
自愈水凝胶
纳米技术
化学
医学
高分子化学
病理
生物化学
替代医学
作者
Pamela Duran,Marianna Alperin,Karen L. Christman
出处
期刊:Biomaterials science series
日期:2019-01-01
卷期号:: 116-138
被引量:1
标识
DOI:10.1039/9781788015998-00116
摘要
Decellularized extracellular matrix hydrogels have a wide variety of tissue engineering and regenerative medicine applications with potential clinical translation. After the decellularization process, the scaffold is partially enzymatically digested, neutralized, and adjusted to physiological pH and salt concentrations. The polymer network then self-assembles with an increase in temperature to 37 °C. This property allows for a minimally-invasive delivery via injection, including catheter delivery. This chapter will discuss the important material properties of ECM hydrogels and possible modifications of the polymer network. Furthermore, in vivo applications in a variety of tissues will be discussed, together with in vitro applications for disease models, drug testing, and toxicology studies.
科研通智能强力驱动
Strongly Powered by AbleSci AI