强力霉素
医学
阿奇霉素
抗生素
克拉霉素
促炎细胞因子
大环内酯类抗生素
鼻窦炎
免疫学
四环素
红霉素
内科学
微生物学
炎症
生物
幽门螺杆菌
作者
Katherine A. Lees,Richard R. Orlandi,Gretchen M. Oakley,Jeremiah A. Alt
标识
DOI:10.1016/j.iac.2019.12.005
摘要
Antibiotic therapy has become an important adjunct in the management of recalcitrant chronic rhinosinusitis (CRS) because of some antibiotics' immunomodulatory properties even at subtherapeutic antimicrobial levels. Macrolide antibiotics, such as clarithromycin and azithromycin, decrease production of proinflammatory cytokines, impair neutrophil recruitment, inhibit bacterial biofilm formation, and improve mucus quality. Doxycycline, a tetracycline antibiotic, inhibits the activity of matrix metalloproteinases in CRS with nasal polyposis. This article reviews the clinical applications for macrolide and doxycycline use in CRS, considerations for dosing and duration of treatment, and important side effects and drug interactions associated with these medications.
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