胶体金
化学
牛血清白蛋白
纳米颗粒
生物分析
纳米技术
共轭体系
生物传感器
组合化学
色谱法
聚合物
有机化学
生物化学
材料科学
作者
Ken Yoshimura,Patmawati,Mizuo Maeda,Noriho Kamiya,Tamotsu Zako
出处
期刊:Analytical Sciences
[Japan Society for Analytical Chemistry]
日期:2020-12-11
卷期号:37 (3): 507-511
被引量:9
标识
DOI:10.2116/analsci.20scp12
摘要
Gold nanoparticles (AuNPs) are commonly used in biosensing applications. In this study, AuNPs were synthesized by using reduced bovine serum albumin (rBSA) as the reducing agent. The rBSA conjugated with AuNPs via Au-Sulfur interactions to form rBSA-functionalized AuNPs (rBSA-AuNPs). The interaction of the rBSA moieties on the rBSA-AuNP surface with an anti-BSA antibody (anti-BSA) led to AuNP aggregation, which enabled the successful detection of anti-BSA at a concentration as low as 20 nM through darkfield microscopy (DFM). This study demonstrates the potential applications of protein-functionalized AuNPs in the bioanalysis of substances through DFM.
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