Ag-catalyzed decarboxylative acylation of pyridazines using α-keto acids in aqueous media

An efficient and general protocol for Ag-Catalyzed decarboxylative acylation of pyridazines using α-keto acids as acylation reagent in aqueous media has been described. This method provides a new avenue for the synthesis of diverse array of acylated pyridazines with different substitution patterns. The reaction proceeds smoothly in water under mild conditions and exhibits a good functional group tolerance.