未折叠蛋白反应
内质网
生物
细胞生物学
拟南芥
蛋白质折叠
蛋白质组
多细胞生物
蛋白质稳态
细胞
计算生物学
基因
生物信息学
生物化学
突变体
作者
Noelia Pastor‐Cantizano,Dae Kwan Ko,Evan Angelos,Yunting Pu,Federica Brandizzí
标识
DOI:10.1016/j.tibs.2019.10.008
摘要
The endoplasmic reticulum (ER) is responsible for the synthesis of one-third of the cellular proteome and is constantly challenged by physiological and environmental situations that can perturb its homeostasis and lead to the accumulation of misfolded secretory proteins, a condition referred to as ER stress. In response, the ER evokes a set of intracellular signaling processes, collectively known as the unfolded protein response (UPR), which are designed to restore biosynthetic capacity of the ER. As single-cell organisms evolved into multicellular life, the UPR complexity has increased to suit their growth and development. In this review, we discuss recent advances in the understanding of the UPR, emphasizing conserved UPR elements between plants and metazoans and highlighting unique plant-specific features.
科研通智能强力驱动
Strongly Powered by AbleSci AI