In the present study a gas/liquid two-phase flow and the simultaneous evaporation and condensation phenomena in a thermosyphon was modeled. The volume of fluid (VOF) technique was used to model the interaction between these phases. Experiments in a thermosyphon were carried out at different operating conditions. The CFD predicted temperature profile in the thermosyphon was compared with experimental measurements and a good agreement was observed. It was concluded that CFD is a useful tool to model and explain the complex flow and heat transfer in a thermosyphon.