碳二亚胺
自愈水凝胶
材料科学
生物相容性
壳聚糖
PEG比率
组织工程
乙二醇
生物医学工程
聚合物
化学工程
高分子化学
复合材料
冶金
经济
工程类
医学
财务
作者
Mehrdad Rafat,Fengfu Li,Per Fagerholm,Neil Lagali,Mitchell A. Watsky,Réjean Munger,Takeshi Matsuura,May Griffith
出处
期刊:Biomaterials
[Elsevier]
日期:2008-07-22
卷期号:29 (29): 3960-3972
被引量:401
标识
DOI:10.1016/j.biomaterials.2008.06.017
摘要
Implantable biomaterials that mimic the extracellular matrix (ECM) in key physical and physiological functions require components and microarchitectures that are carefully designed to maintain the correct balance between biofunctional and physical properties. Our goal was to develop hybrid polymer networks (HPN) that combine the bioactive features of natural materials and physical characteristics of synthetic ones to achieve synergy between the desirable mechanical properties of some components with the biological compatibility and physiological relevance of others. In this study, we developed collagen-chitosan composite hydrogels as corneal implants stabilized by either a simple carbodiimide cross-linker or a hybrid cross-linking system comprised of a long-range bi-functional cross-linker (e.g. poly(ethylene glycol) dibutyraldehyde (PEG-DBA)), and short-range amide-type cross-linkers (e.g. 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), and N-hydroxysuccinimide (NHS)). Optimum hybrid hydrogel demonstrated significantly enhanced mechanical strength and elasticity by 100 and 20%, respectively, compared to its non-hybrid counterpart. It demonstrated excellent optical properties, optimum mechanical properties and suturability, and good permeability to glucose and albumin. It had excellent biocompatibility and when implanted into pig corneas for 12 months, allowed seamless host-graft integration with successful regeneration of host corneal epithelium, stroma, and nerves.
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