Efficacy and Safety of Topical WBI-1001 in the Treatment of Atopic Dermatitis: Results From a Phase 2A, Randomized, Placebo-Controlled Clinical Trial

sion was used to examine which variables of interest would explain unique variance associated with sunbathing intentions and intentions to sun protect.For both analyses, age, sex, skin type, and perceived susceptibility were entered in step 1, followed by the 3 appearance-based tanning motives (appearance reasons to tan, appearance reasons not to tan, and sociocultural influences) entered in step 2. The overall R 2 for both analyses was significant and indicated that a high level of variance was accounted for by the predictors (sunbathing R 2 =.50; sun protection R 2 =.62).In both regressions, appearance subscales of the PARTS explained significant variance beyond that explained by age, sex, skin type, and perceived susceptibility (Table ).Appearance reasons to tan were significantly associated with sunbathing intentions (P Ͻ .01)but not with sun protection intentions (P = .07):adolescents who positively endorsed appearance reasons to tan also reported more frequent intentions to sunbathe in the next 12 months and fewer intentions to sun protect.Appearance reasons not to tan were significantly associated with sunbathing intentions (P=.03) and with sun protection intentions (PϽ.01): participants scoring higher on appearance reasons not to tan also reported fewer intentions to sunbathe and higher intentions to sun protect.Comment.This study suggests that adolescents' sunbathing intentions are enhanced by the belief that tanning will positively impact appearance and are tempered by the belief it will negatively affect appearance.In addition, sun protection intentions are elevated by the belief that sun exposure will negatively affect looks, and reduced by the belief that exposure will improve appearance.These findings replicate our earlier work with adults, demonstrating that appearance factors explain unique variance beyond variables that have received more extensive evaluation, such as perceived susceptibility and skin type.Limitations of the study include the cross-sectional design and the use of self-report as the method of measuring sunbathing and sun protection levels.Additionally, it will be important in future work to compare appearance motives with other factors such as perceived severity of skin cancer and behavioral willingness to engage in risky behaviors.In our group's previous 6-month prospective investigation, 5 we found that appearance motives predicted sunbathing behavior via the mediational role of intentions.Therefore, future work with adolescents might address the potentially important role of appearance motives and intentions to sunbathe or sun protect in the actual prediction of future sunbathing behavior.Overall, this study indicates the potential need for interventions to include strategies designed to challenge appearance motives for tanning.