免疫系统
平衡
抗原
间隙
免疫学
生物
功能(生物学)
免疫耐受
细胞生物学
医学
泌尿科
作者
Luk Van Parijs,Abul K. Abbas
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1998-04-10
卷期号:280 (5361): 243-248
被引量:947
标识
DOI:10.1126/science.280.5361.243
摘要
The immune system responds in a regulated fashion to microbes and eliminates them, but it does not respond to self-antigens. Several regulatory mechanisms function to terminate responses to foreign antigens, returning the immune system to a basal state after the antigen has been cleared, and to maintain unresponsiveness, or tolerance, to self-antigens. Here, recent advances in understanding of the molecular bases and physiologic roles of the mechanisms of immune homeostasis are examined.
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