ABCA1
生物
脂质代谢
ATP结合盒传送带1
细胞生物学
信使核糖核酸
运输机
胆固醇逆向转运
卡尔帕因
生物化学
胆固醇
脂蛋白
酶
基因
作者
Yun-Cheng Lv,Kai Yin,Yuchang Fu,Dawei Zhang,Wujun Chen,Chao‐Ke Tang
标识
DOI:10.1089/dna.2012.1940
摘要
Aim: Several lines of evidence have shown that posttranscriptional regulations play an important role in the modulation of ATP-binding cassette transporter A1 (ABCA1) expression and function. Results: The clearance of ABCA1 mRNA as well as the trafficking, stability, degradation, and activity of the ABCA1 protein are regulated by diverse posttranscriptional mechanisms. ABCA1 mRNA clearance is induced by several microRNAs that result in translational repression and reduction of ABCA1 protein expression. Intracellular ABCA1 trafficking is enhanced toward the plasma membrane, leading to an elevation of cell-surface localization, where the majority of the cholesterol efflux activity occurs. The ABCA1 protein turnover is rapid via calpain-mediated degradation and ubiquitin-mediated degradation. Various modulators retard ABCA1 protein clearance, which raises ABCA1 protein levels. The activity of ABCA1 can also be altered by a few molecules that do not affect ABCA1 protein expression. Conclusion: In this review, we summarize the advances in the knowledge of ABCA1 posttranscriptional regulation, which is warranted to better understand the role of ABCA1 in reverse cholesterol transport, lipid metabolism, and atherosclerosis. ABCA1 may contribute to reverse cholesterol transport, lipid metabolism, and atherosclerosis.
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