致盲
随机对照试验
医学
系统回顾
临床试验
质量(理念)
心理学
物理疗法
梅德林
研究设计
医学物理学
统计
外科
数学
认识论
哲学
病理
政治学
法学
作者
Alejandro R. Jadad,R Andrew Moore,Dawn Carroll,Crispin Jenkinson,David J. Reynolds,David Gavaghan,Henry J McQuay
出处
期刊:Controlled Clinical Trials
[Elsevier]
日期:1996-02-01
卷期号:17 (1): 1-12
被引量:15978
标识
DOI:10.1016/0197-2456(95)00134-4
摘要
It has been suggested that the quality of clinical trials should be assessed by blinded raters to limit the risk of introducing bias into meta-analyses and systematic reviews, and into the peer-review process. There is very little evidence in the literature to substantiate this. This study describes the development of an instrument to assess the quality of reports of randomized clinical trials (RCTs) in pain research and its use to determine the effect of rater blinding on the assessments of quality. A multidisciplinary panel of six judges produced an initial version of the instrument. Fourteen raters from three different backgrounds assessed the quality of 36 research reports in pain research, selected from three different samples. Seven were allocated randomly to perform the assessments under blind conditions. The final version of the instrument included three items. These items were scored consistently by all the raters regardless of background and could discriminate between reports from the different samples. Blind assessments produced significantly lower and more consistent scores than open assessments. The implications of this finding for systematic reviews, meta-analytic research and the peer-review process are discussed.
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