图书馆学
亚特兰大
达芦那韦
人类免疫缺陷病毒(HIV)
化学
医学
计算机科学
抗逆转录病毒疗法
病毒学
病毒载量
大都市区
病理
作者
Arun K. Ghosh,Chunxiao Xu,Kalapala Venkateswara Rao,Abigail Baldridge,Johnson Agniswamy,Yuan‐Fang Wang,Irene T. Weber,Manabu Aoki,Salcedo Gomez Pedro Miguel,Masayuki Amano,Hiroaki Mitsuya
出处
期刊:ChemMedChem
[Wiley]
日期:2010-09-08
卷期号:5 (11): 1850-1854
被引量:49
标识
DOI:10.1002/cmdc.201000318
摘要
A healthier HAART: We report the design, synthesis, biological evaluation, and X-ray crystallographic analysis of a new class of HIV-1 protease inhibitors. Compound 4 proved to be an extremely potent inhibitor toward various multidrug-resistant HIV-1 variants, representing a near 10-fold improvement over darunavir (DRV). Compound 4 also blocked protease dimerization with at least 10-fold greater potency than DRV. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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