植物毒性
三硝基甲苯
环境修复
还原酶
化学
环境化学
经济短缺
污染物
污染
生物
植物
爆炸物
生物化学
酶
有机化学
生态学
哲学
政府(语言学)
语言学
作者
Emily J. Johnston,Elizabeth L. Rylott,Emily Beynon,Astrid Lorenz,Victor Chechik,Neil C. Bruce
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2015-09-04
卷期号:349 (6252): 1072-1075
被引量:82
标识
DOI:10.1126/science.aab3472
摘要
The explosive 2,4,6-trinitrotoluene (TNT) is a highly toxic and persistent environmental pollutant. Due to the scale of affected areas, one of the most cost-effective and environmentally friendly means of removing explosives pollution could be the use of plants. However, mechanisms of TNT phytotoxicity have been elusive. Here, we reveal that phytotoxicity is caused by reduction of TNT in the mitochondria, forming a nitro radical that reacts with atmospheric oxygen, generating reactive superoxide. The reaction is catalyzed by monodehydroascorbate reductase 6 (MDHAR6), with Arabidopsis deficient in MDHAR6 displaying enhanced TNT tolerance. This discovery will contribute toward the remediation of contaminated sites. Moreover, in an environment of increasing herbicide resistance, with a shortage in new herbicide classes, our findings reveal MDHAR6 as a valuable plant-specific target.
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