颞叶
神经科学
心理学
中心性
静息状态功能磁共振成像
扁桃形结构
认知
功能磁共振成像
认知障碍
阿尔茨海默病
疾病
医学
内科学
癫痫
数学
组合数学
作者
Zhenyu Liu,Yumei Zhang,Hao Yan,Lijun Bai,Ruwei Dai,Wen‐Juan Wei,Chongguang Zhong,Ting Xue,Hu Wang,Yuanyuan Feng,Youbo You,Xinghu Zhang,Jie Tian
标识
DOI:10.1016/j.pscychresns.2012.03.002
摘要
Recent studies have shown that cognitive and memory decline in patients with Alzheimer's disease (AD) is coupled with losses of small-world attributes. However, few studies have investigated the characteristics of the whole brain networks in individuals with mild cognitive impairment (MCI). In this functional magnetic resonance imaging (fMRI) study, we investigated the topological properties of the whole brain networks in 18 AD patients, 16 MCI patients, and 18 age-matched healthy subjects. Among the three groups, AD patients showed the longest characteristic path lengths and the largest clustering coefficients, while the small-world measures of MCI networks exhibited intermediate values. The finding was not surprising, given that MCI is considered to be the prodromal stage of AD. Compared with normal controls, MCI patients showed decreased nodal centrality mainly in the medial temporal lobe as well as increased nodal centrality in the occipital regions. In addition, we detected increased nodal centrality in the medial temporal lobe and frontal gyrus, and decreased nodal centrality mainly in the amygdala in MCI patients compared with AD patients. The results suggested a widespread rewiring in AD and MCI patients. These findings concerning AD and MCI may be an integrated reflection of reorganization of the brain networks accompanied with the cognitive decline that may lead to AD.
科研通智能强力驱动
Strongly Powered by AbleSci AI