Synthesis of (R)‐(−)‐Muscone from (R)‐5‐Bromo‐4‐methylpentanoate: A Chiron Approach

Abstract A synthesis of ( R )‐muscone ( 1 ), a valuable musk odorant, is presented. The stereogenic center of muscone was introduced from methyl ( R )‐5‐bromo‐4‐methylpentanoate ( 5 ), a chiral pool molecule developed in our group, and the macrocyclic ring was prepared by ring‐closing metathesis (RCM) reaction.