苯扎溴铵
山梨酸钾
防腐剂
医学
鼻粘膜
体外
微生物学
药理学
毒性
化学
生物化学
病理
食品科学
生物
内科学
糖
作者
Ching‐Yin Ho,Meng-Chuan Wu,Ming‐Ying Lan,Ching‐Ting Tan,An‐Hang Yang
出处
期刊:American Journal of Rhinology
[SAGE]
日期:2008-03-01
卷期号:22 (2): 125-129
被引量:30
标识
DOI:10.2500/ajr.2008.22.3154
摘要
Background The preservatives benzalkonium chloride and potassium sorbate are widely used in nasal drops and sprays. Recently, side effects resulting from mucosal damage caused by benzalkonium chloride and potassium sorbate were reported. Methods We investigated the toxicity of benzalkonium chloride and potassium sorbate on human nasal epithelial cells in vitro. Using primary human nasal epithelial cells, different concentrations of benzalkonium chloride, potassium sorbate, or phosphate-buffered saline (PBS; control group) solutions were cocultured with nasal epithelial cells for 15 minutes. Then, the viability of the cells and the cell morphology were assessed. Results Nasal epithelial cells were more severely damaged with use of clinical preparations or higher concentrations of benzalkonium chloride than in the control group. In addition, nasal epithelial cell membrane lysis was seen on electronic microscopy in the benzalkonium chloride groups. In contrast, there was no significant cell damage seen in the potassium sorbate groups compared with the control group, even with higher concentrations than clinically used. Conclusion Potassium sorbate appears to be a relatively safer preservative than benzalkonium chloride for use in nasal sprays and drops in vitro study.
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