一氧化氮
毒性
马来丝虫
化学
硫醇
纳米颗粒
生物化学
纳米技术
丝虫病
医学
免疫学
材料科学
有机化学
蠕虫
作者
Alex Schudel,Timothy Kassis,J. Brandon Dixon,Susan N. Thomas
标识
DOI:10.1002/adhm.201400841
摘要
A synthetic polymer nanoparticle formulation utilizing the physiological nitrosothiol chemistry for nitric oxide delivery is shown. Toxicity of S-nitroso nanoparticles against adult female Brugia malayi worms, which are responsible for lymphatic filariasis, is dependent on nitric oxide release through transnitrosation as S-nitrosocysteine, a potent endogenous nitric oxide donor.
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