Renal Cell Carcinoma as First and Second Primary Cancer: Etiological Clues From the Swedish Family-Cancer Database

No AccessJournal of UrologyAdult Urology1 Jun 2011Renal Cell Carcinoma as First and Second Primary Cancer: Etiological Clues From the Swedish Family-Cancer Database Hao Liu, Kari Hemminki, and Jan Sundquist Hao LiuHao Liu Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany , Kari HemminkiKari Hemminki Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany Center for Primary Health Care Research, Lund University, Malmö, Sweden , and Jan SundquistJan Sundquist Center for Primary Health Care Research, Lund University, Malmö, Sweden Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, California View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.001AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: An increasing incidence and improved prognosis of kidney cancer have led to concern about second primary malignancies. The study of multiple primary malignancies is also important since the association of certain malignancies may guide the search for germline alterations and environmental risk factors. We evaluated bidirectional associations between renal cell carcinoma and other primary cancers. Materials and Methods: We studied 8,030 patients with renal cell carcinoma based on the Swedish Family-Cancer Database. The SIR of second cancer was calculated by comparing it to the rate of first cancers. Followup was started in 1993 and continued through 2006. Results: A total of 677 patients had second cancers after the first renal cell carcinoma, including 89 second renal cell carcinomas. In 776 patients renal cell carcinoma was diagnosed after another primary cancer. Histology concordant renal cell carcinoma pairs showed a SIR of 31.04 and 15.15 after clear cell and total renal cell carcinoma, respectively. The highest SIR of 132.46 was noted for synchronous contralateral clear cell renal cell carcinoma. 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Google Scholar © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByGuo B and Liu M (2021) Renal Cell Carcinoma: Comparison between Variant Histology and Clear Cell Carcinoma across All Stages and Treatment Modalities. Letter.Journal of Urology, VOL. 205, NO. 5, (1525-1525), Online publication date: 1-May-2021.Laguna M (2015) Re: International Variations and Trends in Renal Cell Carcinoma Incidence and MortalityJournal of Urology, VOL. 194, NO. 4, (950-951), Online publication date: 1-Oct-2015.Laguna M (2013) Re: An Investigation of Risk Factors for Renal Cell Carcinoma by Histologic Subtype in Two Case-Control StudiesJournal of Urology, VOL. 191, NO. 1, (55-55), Online publication date: 1-Jan-2014. Volume 185Issue 6June 2011Page: 2045-2049 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.Keywordsriskneoplasmsrenal cellkidneycarcinomaetiologysecond primaryAcknowledgmentsThe Family-Cancer Database was created by linking registries maintained at Statistics Sweden and the Swedish Cancer Registry.MetricsAuthor Information Hao Liu Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany More articles by this author Kari Hemminki Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany Center for Primary Health Care Research, Lund University, Malmö, Sweden More articles by this author Jan Sundquist Center for Primary Health Care Research, Lund University, Malmö, Sweden Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, California More articles by this author Expand All Advertisement PDF DownloadLoading ...