p38丝裂原活化蛋白激酶
激酶
生物
MAPK/ERK通路
丝裂原活化蛋白激酶
细胞生物学
信号转导
细胞凋亡
蛋白激酶A
ASK1
丝裂原活化蛋白激酶激酶
生物化学
作者
Teiji Wada,Josef Penninger
出处
期刊:Oncogene
[Springer Nature]
日期:2004-04-12
卷期号:23 (16): 2838-2849
被引量:1288
标识
DOI:10.1038/sj.onc.1207556
摘要
Cells are continuously exposed to a variety of environmental stresses and have to decide ‘to be or not to be’ depending on the types and strength of stress. Among the many signaling pathways that respond to stress, mitogen-activated protein kinase (MAPK) family members are crucial for the maintenance of cells. Three subfamilies of MAPKs have been identified: extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinases (JNKs), and p38-MAPKs. It has been originally shown that ERKs are important for cell survival, whereas JNKs and p38-MAPKs were deemed stress responsive and thus involved in apoptosis. However, the regulation of apoptosis by MAPKs is more complex than initially thought and often controversial. In this review, we discuss MAPKs in apoptosis regulation with attention to mouse genetic models and critically point out the multiple roles of MAPKs.
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