神经发生
齿状回
海马结构
海马体
溴脱氧尿苷
生物
神经科学
信号转导
内分泌学
内科学
细胞生物学
医学
细胞生长
遗传学
出处
期刊:The Journals of Gerontology
[Oxford University Press]
日期:2007-02-01
卷期号:62 (2): 117-125
被引量:36
标识
DOI:10.1093/gerona/62.2.117
摘要
Ames dwarf mice live considerably longer than normal animals, exhibit apparently normal cognitive functions, and maintain them into advanced age. Neurogenesis occurs throughout adult life span in the dentate gyrus of mammalian hippocampus and has been suggested to play an important role in cognitive function. We now report that the total number of bromodeoxyuridine (BrdU)-labeled cells in this brain region in aged Ames dwarf mice was not different from that in aged normal mice, whereas the fraction of newly generated neurons was significantly increased by monitoring BrdU labeling and cell marker expression. Evidence of activation of antiapoptosis signal transduction cascade was also found in the hippocampus of aged dwarf mice. Together with previous findings, the results may suggest that an increase in hippocampal insulin-like growth factor-I protein expression and subsequent activation of antiapoptotic signaling might contribute to survival of newly born neurons and subsequently to the delay of cognitive loss during aging in these long-lived dwarf mice.
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