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Lymph node staging by means of positron emission tomography is less accurate in non-small cell lung cancer patients with enlarged lymph nodes: Analysis of 1145 lymph nodes

医学 纵隔镜检查 淋巴 淋巴结 正电子发射断层摄影术 肺癌 放射科 PET-CT 断层摄影术 核医学 病理
作者
Nael Al-Sarraf,Kathy Gately,Julie Lucey,Lorraine Wilson,Eillish McGovern,Vincent Young
出处
期刊:Lung Cancer [Elsevier BV]
卷期号:60 (1): 62-68 被引量:68
标识
DOI:10.1016/j.lungcan.2007.08.036
摘要

Background Despite documented superiority of integrated positron emission tomography-computerized tomography (PET-CT) over computerized tomography (CT) in lymph node staging in non-small cell lung cancer, little is known about the sensitivity, specificity and accuracy of integrated PET-CT among enlarged lymph nodes. We sought to assess if PET-CT is uniformly accurate among enlarged and non-enlarged lymph nodes. Methods A retrospective review of 206 consecutive patients with histologically proven non-small cell lung cancer who underwent resection and/or mediastinoscopy in our centre over 30 months period was carried out. All these patients had pre-operative staging with integrated PET-CT as an adjunct to chest CT prior to resection and/or mediastinoscopy. Diabetic patients (BM ≥ 8.0 mmol/l) and those who received neo-adjuvant chemotherapy were excluded. The pathological results of all these cases were reviewed and correlated with those on CT and integrated PET-CT. Results The sensitivity, specificity, accuracy, positive and negative predictive values were higher in integrated PET-CT than CT alone in all lymph nodes, whether N1 or N2. When lymph nodes were stratified by size, the sensitivity of PET-CT was significantly higher among enlarged (>1 cm) than non-enlarged (≤1 cm) lymph nodes (74% vs. 40%, P < 0.0001), but with a significantly lower specificity (81% vs. 98%, P < 0.0001) and a lower accuracy (78% vs. 90%, P 0.008). Conclusions Integrated PET-CT remains superior to CT in nodal staging of non-small cell lung cancer. However, in the presence of enlarged lymph nodes, PET-CT becomes less specific, less accurate but more sensitive in detecting metastatic spread to the lymph nodes. Interpretation of PET-CT findings in NSCLC patients with enlarged lymph nodes (>1 cm) should be with caution as the specificity of PET-CT is lower and its ability to detect truly negative nodes become reduced. NSCLC patients with enlarged nodes by CT criteria who are PET-CT negative may require cervical mediastinoscopy to rule out metastatic spread to these nodes. Prospective studies are warranted.
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