试剂
硅烷化
硝基
化学
炔烃
乙炔
药物化学
四级碳
组合化学
有机化学
催化作用
对映选择合成
烷基
作者
Davinia Fernández González,Jérôme Waser,Jérôme Waser
标识
DOI:10.1002/chem.201001539
摘要
Hot alkyne! The in situ generation of ethynyl-1,2-benziodoxol-3(1H)-one (EBX) from a silyl-protected reagent by using TBAF is reported. EBX displayed exceptional acetylene transfer ability onto stabilized enolates (see scheme), even at −78 °C. The mild reaction conditions allowed the first ethynylation reactions of linear keto, cyano, and nitro esters in high yields to give all-carbon quaternary centers or non-natural amino acids after selective reduction of the nitro group.
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