生物
基因
神经退行性变
疾病
细胞生物学
蛋白质折叠
医学
蛋白质聚集
神经科学
遗传学
病理
作者
J. Paul Taylor,John Hardy,Kenneth H. Fischbeck
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2002-06-14
卷期号:296 (5575): 1991-1995
被引量:1172
标识
DOI:10.1126/science.1067122
摘要
A broad range of neurodegenerative disorders is characterized by neuronal damage that may be caused by toxic, aggregation-prone proteins. As genes are identified for these disorders and cell culture and animal models are developed, it has become clear that a major effect of mutations in these genes is the abnormal processing and accumulation of misfolded protein in neuronal inclusions and plaques. Increased understanding of the cellular mechanisms for disposal of abnormal proteins and of the effects of toxic protein accumulation on neuronal survival may allow the development of rational, effective treatment for these disorders.
科研通智能强力驱动
Strongly Powered by AbleSci AI