生物相容性
微核试验
艾姆斯试验
磷酸镁
骨水泥
染色体畸变
固定(群体遗传学)
镁
遗传毒性
生物医学工程
毒性
水泥
磷酸盐
化学
材料科学
生物
医学
生物化学
遗传学
基因
复合材料
染色体
有机化学
沙门氏菌
细菌
作者
Yu Yong,Jing Wang,Changsheng Liu,Bingwen Zhang,Honghong Chen,Han Guo,Gaoren Zhong,Weidong Qu,Songhui Jiang,Huang Huang-yuan
标识
DOI:10.1016/j.colsurfb.2009.12.010
摘要
Magnesium phosphate cement (MPC) is a kind of novel biodegradable bone adhesive for its distinct performance. However, there is few research work concerning on the systemic biocompatibility and genetic toxicological evaluation of MPC. In this study, the investigation on the inherited toxicology of MPC including gene mutation assay (Ames test), chromosome aberration assay (micronucleus test), and DNA damage assay (unscheduled DNA synthesis test) were carried out. Fracture healing and degradation behavior were explored for the evaluation of the biocompatibility of MPC, using macroscopical histological, histomorphometrical, and scanning electron microscopical methods. The results of mutagenicity and potential carcinogenicity of MPC extracts were negative, and the animal implantation illustrated no toxicity and good resorption. The study suggested that bioresorbable MPC was safe for application and might have potential applications for physiological fracture fixation.
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