载脂蛋白E
基因型
优势比
医学
等位基因
疾病
内科学
风险因素
胃肠病学
内分泌学
遗传学
基因
生物
作者
Kwan‐Fu Rex Sheu,Sudha Seshadri,Bruce S. Kristal,Rajesh N. Kalaria,Lena Lilius,Patrik K. E. Magnusson,John P. Blass
出处
期刊:Neurology
[Ovid Technologies (Wolters Kluwer)]
日期:1999-04-01
卷期号:52 (7): 1505-1505
被引量:25
标识
DOI:10.1212/wnl.52.7.1505
摘要
Recent studies suggest that variants of the DLST gene alter the risk of AD. DLST encodes the core subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which is deficient in AD. The authors report that in 247 US white subjects, homozygosity for DLST A19,117, T19,183 was associated with a reduced risk of AD (odds ratio [OR] = 0.35, p = 0.018). The reduced risk was marked in subjects who did not carry the apolipoprotein (APOE)-4 allele (OR = 0.16, p = 0.014). Further study of DLST in AD appears warranted.
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