胶束
药物输送
药品
全身循环
血液循环
毒品携带者
纳米技术
化学
生化工程
材料科学
药理学
医学
有机化学
内科学
工程类
水溶液
传统医学
作者
Yang Lü,Ershuai Zhang,Jianhai Yang,Zhiqiang Cao
出处
期刊:Nano Research
[Springer Nature]
日期:2018-08-01
卷期号:11 (10): 4985-4998
被引量:333
标识
DOI:10.1007/s12274-018-2152-3
摘要
Micelles have been studied as drug delivery carriers for decades. Their use can potentially result in high drug accumulation at the target site through the enhanced permeability and retention effect. Nevertheless, the lack of stability of micelles in the physiological environment limits their efficacy as a drug carrier. In particular, micelles tend to disassociate and prematurely release the encapsulated drugs, lowering delivery efficacy and creating toxicity concerns. Many efforts to enhance the stability of micelles have focused mainly on decreasing the critical micelle forming concentration and improving blood circulation. Herein, we review different strategies including crosslinking and non-crosslinking approaches designed to stabilize micelles and offer perspectives on future research directions.
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