作者
Deesha Ghorpade,Sheetu Singh,Deepak Talwar,Sagar Chandrashekariah,Surya Kant,Rajesh Swarnakar,Srinivas Rajagopala,George D’Souza,Arjun Padmanabhan,Archana Baburao,P A Mahesh,Sonali Trivedi,Babaji Ghewade,Aditya Jindal,Girija Nair,Devi H.J. Gayathri,Kripesh Ranjan Sarmah,Honney Sawhney,Kaushik Saha,Arjun Khanna,Samir Gami,Anantharaj Suresh,Arpan Shah,Naveen Dutt,Arti Shah,Himanshu Garg,Sunil Vyas,Kummannoor Venugopal,Rajendra Prasad,Saurabh Karmakar,Virendra Singh,Shubham Sharma,Shivani Saxena,Preethi Vasudev,Jayaraj Biligere Siddaiah,Rahul Kungwani,Akanksha Das,Palak Shah,Anshul Mangla,Nikita Jajodia,Harsh Saxena,Sapna Madas,Sneha Limaye,Sundeep Salvi,Stefano Alberti,James D. Chalmers,Raja Dhar
摘要
Introduction and Methods: The European Multicenter Bronchiectasis Audit and Research Collaboration (EMBARC) network established across 23 European countries was extended to India to explore unique features of Non-cystic fibrosis Bronchiectasis in this sub-continent. 34 investigator sites located across different parts of India contributed to 2062 cases of Non-CF Bronchiectasis, of which post-tuberculosis lung disease was identified as the biggest risk factor contributing to 34.7% (N=717) cases. The aim of this study was to describe the unique features of Post-TB Bronchiectasis observed on HRCT in this Indian cohort. Results: The mean (± SD) age of the 717 cases of Post-TB Bronchiectasis was 54.9 ± 14 yrs with a M:F ratio of 60:40. The location of Bronchiectasis was 71% (67.7,74.3) in the upper lobes, 66% (62.5,69.5) in the middle lobe/lingula and 60% (56.4,63.6) in the lower lobes. The cystic type was the most common 56% (53.1,60.4), followed by cylindrical 46% (42.3,49.6) and varicose 8.9% (6.8,10.9). More than 43.8% had bilateral disease. 13.6% (11.3,16.3) of the cases presented with hemoptysis that required hospitalization. Sputum microbiological samples collected in 39.8% of the cases isolated Pseudomonas in 17.1% during stable disease and 18.9% during exacerbations, while Klebsiella was isolated in 4.5% and 16.0% of cases respectively. Myco TB was isolated in the sputum in 5% of cases. 39.5% of the subjects had FEV1/FVC values <0.7 and 56% of the cases received inhaled corticosteroids. Conclusion: Post TB lung disease is the commonest cause for Non CF Bronchiectasis in India and presents with unique features that are distinct from those reported in the western world.