In cases requiring extraction of four first premolars, ensuring maintenance of adequate posterior anchorage and proper inclination of the teeth adjacent to the extraction sites during space closure can be difficult. The Invisalign G6 first premolar extraction solution has been developed to specifically address these problems. This case report describes the treatment of a 30-year-old woman whose main concerns were related to her protrusive and malaligned anterior teeth. Clinical findings revealed, among others, bimaxillary anterior protrusion and moderate-to-severe anterior crowding. A treatment approach involving extraction of the four first premolars was chosen, followed by orthodontic treatment with the Invisalign G6 first premolar extraction solution and Invisalign aligners. At the completion of 19.5 months of aligner treatment, the patient’s anterior teeth were retracted and uprighted, resulting in an improvement in her lip profile. Normal overjet and overbite were also achieved along with alleviation of the anterior crowding. The patient was extremely happy with the treatment results.