Synthesis and antifungal activity of a series of difluorotritylimidazoles.

1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole (flutrimazole, UR-4056, CAS 119006-77-8) (15) was selected among a series of mono-, di- and tri-fluorotrityl-imidazole antifungal agents as the most potent fluorine containing analogue of clotrimazole