Studies on Aryl H-Phosphonates; Part 2: A General Method for the Preparation of Alkyl H-Phosphonate Monoesters

A simple and efficient synthetic method for the preparation of alkyl H-phosphonate monoesters has been developed. The method consists of transesterification of commercially available diphenyl H-phosphonate with an appropriate alcohol under mild conditions, followed by ammonolysis of the in situ formed dialkyl and alkyl phenyl H-phosphonates.