已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Embryonic stem cell- and transcriptomics-based in vitro analyses reveal that bisphenols A, F and S have similar and very complex potential developmental toxicities

胚胎干细胞 生物 干细胞 转录组 祖细胞 胚状体 细胞生物学 发育毒性 神经干细胞 细胞分化 诱导多能干细胞 遗传学 基因 基因表达 妊娠期 怀孕
作者
Nuoya Yin,Xiaoxing Liang,Shengxian Liang,Siwei Liang,Renjun Yang,Bowen Hu,Zhanwen Cheng,Shuyu Liu,Hengzhi Dong,Sijin Liu,Francesco Faiola
出处
期刊:Ecotoxicology and Environmental Safety [Elsevier]
卷期号:176: 330-338 被引量:46
标识
DOI:10.1016/j.ecoenv.2019.03.115
摘要

Bisphenol A (BPA) is a very versatile industrial chemical. Many reports have associated BPA with several health effects. Some bisphenol alternatives have been introduced to replace BPA in its many applications. However, comprehensive toxicological evaluations for these replacements are still lacking. In this study, we examined the potential effects of BPA, bisphenol F (BPF) and bisphenol S (BPS), on embryonic development with an in vitro stem cell toxicology system and transcriptomics analyses. Mouse embryonic stem cells (mESCs) were differentiated via embryoid body formation, either globally towards the three primary germ layers and their lineages, or specifically into neuroectoderm/neural progenitor cells. During the differentiation, cells were treated with BPA, BPF, BPS, or DMSO control. Samples were collected at different time points, for qRT-PCR and RNA-seq analyses. BPA, BPF and BPS disrupted many processes, during mESC global and neural differentiations, in very similar manners. In fact, at each time point the three chemicals differentially regulated analogous gene categories, particularly the ones involved in cell-matrix and cell-cell adhesion, signal transduction pathways, and medical conditions such as cardiovascular diseases and cancer. Our findings demonstrate once more then BPA substitutes may not be very safe. They potentially have a very complex developmental toxicity, similarly to BPA, and seem more toxic than BPA itself. In addition, our results reveal that stem cell-based developmental toxicity assays can be very comprehensive.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
3秒前
eno完成签到,获得积分10
5秒前
桃桃奶盖发布了新的文献求助10
6秒前
6秒前
小路完成签到,获得积分10
6秒前
ating发布了新的文献求助10
7秒前
7秒前
小仙女完成签到 ,获得积分10
9秒前
沙心发布了新的文献求助200
11秒前
小二郎应助哆啦梦采纳,获得20
11秒前
13秒前
小唐发布了新的文献求助10
13秒前
咩咩发布了新的文献求助30
13秒前
15秒前
充电宝应助May采纳,获得30
15秒前
16秒前
谦让的傲云完成签到,获得积分10
16秒前
believe完成签到,获得积分10
32秒前
叮叮叮铛完成签到,获得积分10
34秒前
超级芷文完成签到,获得积分20
36秒前
37秒前
车小帅完成签到,获得积分10
37秒前
39秒前
39秒前
42秒前
搜集达人应助毕十三采纳,获得10
43秒前
幽幽完成签到 ,获得积分10
44秒前
44秒前
46秒前
wyy应助正直冰安采纳,获得10
50秒前
nusiew发布了新的文献求助10
50秒前
运气爆棚完成签到,获得积分10
51秒前
桃桃奶盖完成签到,获得积分10
51秒前
paleo-地质完成签到,获得积分10
52秒前
中中发布了新的文献求助10
54秒前
赘婿应助风一样的我采纳,获得10
55秒前
酷波er应助笨蛋没烦恼采纳,获得10
56秒前
科研通AI2S应助CXJ采纳,获得10
57秒前
58秒前
zorro3574完成签到,获得积分10
1分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
Handbook on People's China (1957) 400
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3189626
求助须知:如何正确求助?哪些是违规求助? 2838992
关于积分的说明 8022281
捐赠科研通 2501786
什么是DOI,文献DOI怎么找? 1336060
科研通“疑难数据库(出版商)”最低求助积分说明 637750
邀请新用户注册赠送积分活动 605833