清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Embryonic stem cell- and transcriptomics-based in vitro analyses reveal that bisphenols A, F and S have similar and very complex potential developmental toxicities

胚胎干细胞 生物 干细胞 转录组 祖细胞 胚状体 细胞生物学 发育毒性 神经干细胞 细胞分化 诱导多能干细胞 遗传学 基因 基因表达 妊娠期 怀孕
作者
Nuoya Yin,Xiaoxing Liang,Shengxian Liang,Siwei Liang,Renjun Yang,Bowen Hu,Zhanwen Cheng,Shuyu Liu,Hengzhi Dong,Sijin Liu,Francesco Faiola
出处
期刊:Ecotoxicology and Environmental Safety [Elsevier]
卷期号:176: 330-338 被引量:46
标识
DOI:10.1016/j.ecoenv.2019.03.115
摘要

Bisphenol A (BPA) is a very versatile industrial chemical. Many reports have associated BPA with several health effects. Some bisphenol alternatives have been introduced to replace BPA in its many applications. However, comprehensive toxicological evaluations for these replacements are still lacking. In this study, we examined the potential effects of BPA, bisphenol F (BPF) and bisphenol S (BPS), on embryonic development with an in vitro stem cell toxicology system and transcriptomics analyses. Mouse embryonic stem cells (mESCs) were differentiated via embryoid body formation, either globally towards the three primary germ layers and their lineages, or specifically into neuroectoderm/neural progenitor cells. During the differentiation, cells were treated with BPA, BPF, BPS, or DMSO control. Samples were collected at different time points, for qRT-PCR and RNA-seq analyses. BPA, BPF and BPS disrupted many processes, during mESC global and neural differentiations, in very similar manners. In fact, at each time point the three chemicals differentially regulated analogous gene categories, particularly the ones involved in cell-matrix and cell-cell adhesion, signal transduction pathways, and medical conditions such as cardiovascular diseases and cancer. Our findings demonstrate once more then BPA substitutes may not be very safe. They potentially have a very complex developmental toxicity, similarly to BPA, and seem more toxic than BPA itself. In addition, our results reveal that stem cell-based developmental toxicity assays can be very comprehensive.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
youziyou发布了新的文献求助10
7秒前
youziyou完成签到,获得积分10
15秒前
新时代好青年完成签到,获得积分10
18秒前
Billy应助新时代好青年采纳,获得30
34秒前
oracl完成签到 ,获得积分10
1分钟前
矢思然完成签到,获得积分10
1分钟前
amar完成签到 ,获得积分0
1分钟前
碧蓝的尔竹完成签到,获得积分10
1分钟前
woxinyouyou完成签到,获得积分0
2分钟前
SciGPT应助may采纳,获得10
2分钟前
Zhangfu完成签到,获得积分10
2分钟前
2分钟前
janice发布了新的文献求助10
2分钟前
蚂蚱完成签到 ,获得积分10
3分钟前
完美世界应助steleegee采纳,获得10
3分钟前
FashionBoy应助HS采纳,获得10
3分钟前
Eri_SCI完成签到 ,获得积分10
3分钟前
bkagyin应助东明采纳,获得10
3分钟前
3分钟前
HS发布了新的文献求助10
4分钟前
4分钟前
东明发布了新的文献求助10
4分钟前
4分钟前
华仔应助janice采纳,获得10
4分钟前
东明完成签到,获得积分10
4分钟前
4分钟前
晨曦完成签到,获得积分10
4分钟前
4分钟前
steleegee发布了新的文献求助10
5分钟前
5分钟前
5分钟前
Richard完成签到 ,获得积分10
5分钟前
5分钟前
janice发布了新的文献求助10
5分钟前
碗碗豆喵完成签到 ,获得积分10
6分钟前
janice发布了新的文献求助10
6分钟前
SciGPT应助janice采纳,获得10
6分钟前
may完成签到,获得积分10
6分钟前
6分钟前
高分求助中
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
A prescription for engineering PFAS biodegradation 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3183739
求助须知:如何正确求助?哪些是违规求助? 2833779
关于积分的说明 7995556
捐赠科研通 2496028
什么是DOI,文献DOI怎么找? 1331874
科研通“疑难数据库(出版商)”最低求助积分说明 636441
邀请新用户注册赠送积分活动 603625