Structural Diversity Attributed by Aza-Diels-Alder Reaction in Synthesis of Diverse Quinoline Scaffolds

In recent years, the synthesis of quinoline scaffold using various methodological devices has attracted considerable attention in synthetic chemist community. The most feasible method to serve this purpose is Aza-Diels-Alder reaction which provides flexibility and diversity in the synthesis of quinoline decorated with different functionalities over the scaffold. Diversity in this functionality improvises the susceptibility of the quinoline scaffold for various protein targets. This review encompasses multifactorial aspects of Aza-Diels-Alder reaction as well as provides insights into the synthetic schemes for quinoline scaffold.