Changing views in cardiometabolic disease

Metabolism Branched-chain amino acids (BCAAs) are a subset of essential amino acids that are acquired from the diet. In a Perspective, White and Newgard discuss the evidence linking increased circulating BCAAs with obesity-associated conditions, including type 2 diabetes and cardiovascular diseases. The authors discuss how BCAAs can provide biomarkers of cardiometabolic health and also the mechanisms by which BCAAs promote phenotypes of cardiometabolic disease. Science , this issue p. [582][1] [1]: /lookup/doi/10.1126/science.aav0558