摩尔分数
青蒿琥酯
甲醇
溶解度
化学
溶剂
乙醇
质量分数
分数(化学)
有机化学
物理化学
生物
免疫学
疟疾
恶性疟原虫
作者
Renjie Xu,Ting Han,Li Shen,Jianguo Zhao,Xiang’an Lu
标识
DOI:10.1021/acs.jced.8b00988
摘要
Artesunate is dissolved in an aqueous solution of several organic solvents (methanol, ethanol, isopropanol, and PG), and the mole fraction of artesunate is determined by the static method. When the system reaches equilibrium, the range of system temperature is 278.15–318.15 K and the pressure environment is 101.1 kPa. When the temperature is constant, the equilibrium mole fraction of artesunate is proportional to the mass percentage of organic solvents, and the relationship between artesunate solubility and temperature is the same as before under certain conditions of the organic solvent component. When the external conditions are the same, artesunate is more likely to dissolve in the ethanol + water mixture than in several other systems. Besides, three classical mixed solvent thermodynamic equations—Jouyban–Acree model, van't Hoff–Jouyban–Acree model, and Apelblat–Jouyban–Acree model—are applied to calculate the equilibrium mole fraction of artesunate. The maximum value of average relative deviations (ARD) obtained during the calculation is 0.83%. The experimentally measured data on artesunate has different general meanings for the expansion of application and production in the pharmaceutical field and provides theoretical data for its industrial production.
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