General Overview on Cyclodextrin-Based Artificial Enzymes'; Activity

Artificial enzymes have emerged as cheaper, more robust and chemically malleable alternatives for natural enzymes in the chemical reactions. The importance of cyclodextrin nanoreactors with the hydrophilic exterior surface and the hydrophobic interior core as host structures in artificial enzymes designing has attracted special attention over the last years. The aim of the present paper is to review three different categories of cyclodextrin- based artificial enzymes including metal free cyclodextrin-based artificial enzymes, cyclodextrin-based artificial metalloenzymes and cyclodextrin-based artificial enzymes with computational design, focusing on their rate acceleration factor. Each of the three categories mimics enzymes such as oxidase, reductase, dehydrogenase, esterase, aminotransferase, glycosidase, protease, nuclease etc., which are accompanied by the comprehensive information about the relationship between their structure and activity. Keywords: Cyclodextrin nanoreactor, artificial enzyme, metalloenzyme, computational enzyme design, enzyme's activity, rate acceleration factor.