神经科学
扁桃形结构
生物神经网络
多巴胺
加巴能
光遗传学
杏仁核
摄食行为
机制(生物学)
伏隔核
生物
食物消费
扩大杏仁核
下丘脑
中边缘通路
心理学
抑制性突触后电位
被盖腹侧区
内分泌学
多巴胺能
哲学
经济
认识论
农业经济学
作者
Amelia M. Douglass,Hakan Kucukdereli,Marion Ponserre,Milica Marković,Jan Gründemann,Cornelia Strobel,Pilar L. Alcala Morales,Karl‐Klaus Conzelmann,Andreas Lüthi,Rüdiger Klein
摘要
The complex behaviors underlying reward seeking and consumption are integral to organism survival. The hypothalamus and mesolimbic dopamine system are key mediators of these behaviors, yet regulation of appetitive and consummatory behaviors outside of these regions is poorly understood. The central nucleus of the amygdala (CeA) has been implicated in feeding and reward, but the neurons and circuit mechanisms that positively regulate these behaviors remain unclear. Here, we defined the neuronal mechanisms by which CeA neurons promote food consumption. Using in vivo activity manipulations and Ca2+ imaging in mice, we found that GABAergic serotonin receptor 2a (Htr2a)-expressing CeA neurons modulate food consumption, promote positive reinforcement and are active in vivo during eating. We demonstrated electrophysiologically, anatomically and behaviorally that intra-CeA and long-range circuit mechanisms underlie these behaviors. Finally, we showed that CeAHtr2a neurons receive inputs from feeding-relevant brain regions. Our results illustrate how defined CeA neural circuits positively regulate food consumption.
科研通智能强力驱动
Strongly Powered by AbleSci AI