Transcriptional Regulation of Adipogenesis

Transcriptional Regulation of Adipogenesis Volume 7 Issue 2. April 2017 Paula Mota de Sá, Paula Mota de Sá Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USAPaula Mota de Sá and Allison J. Richard contributed equally to the preparation of the article.Search for more papers by this authorAllison J. Richard, Allison J. Richard Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USAPaula Mota de Sá and Allison J. Richard contributed equally to the preparation of the article.Search for more papers by this authorHardy Hang, Hardy Hang Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USASearch for more papers by this authorJacqueline M. Stephens, Jacqueline M. Stephens jsteph1@lsu.edu Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USASearch for more papers by this author Paula Mota de Sá, Paula Mota de Sá Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USAPaula Mota de Sá and Allison J. Richard contributed equally to the preparation of the article.Search for more papers by this authorAllison J. Richard, Allison J. Richard Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USAPaula Mota de Sá and Allison J. Richard contributed equally to the preparation of the article.Search for more papers by this authorHardy Hang, Hardy Hang Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USASearch for more papers by this authorJacqueline M. Stephens, Jacqueline M. Stephens jsteph1@lsu.edu Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USASearch for more papers by this author Published online: 16 March 2017 https://doi.org/10.1002/cphy.c160022Citations: 199 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat ABSTRACT Adipocytes are the defining cell type of adipose tissue. Once considered a passive participant in energy storage, adipose tissue is now recognized as a dynamic organ that contributes to several important physiological processes, such as lipid metabolism, systemic energy homeostasis, and whole-body insulin sensitivity. Therefore, understanding the mechanisms involved in its development and function is of great importance. Adipocyte differentiation is a highly orchestrated process which can vary between different fat depots as well as between the sexes. While hormones, miRNAs, cytoskeletal proteins, and many other effectors can modulate adipocyte development, the best understood regulators of adipogenesis are the transcription factors that inhibit or promote this process. Ectopic expression and knockdown approaches in cultured cells have been widely used to understand the contribution of transcription factors to adipocyte development, providing a basis for more sophisticated in vivo strategies to examine adipogenesis. To date, over two dozen transcription factors have been shown to play important roles in adipocyte development. These transcription factors belong to several families with many different DNA-binding domains. While peroxisome proliferator-activated receptor gamma (PPARγ) is undoubtedly the most important transcriptional modulator of adipocyte development in all types of adipose tissue, members of the CCAAT/enhancer-binding protein, Krüppel-like transcription factor, signal transducer and activator of transcription, GATA, early B cell factor, and interferon-regulatory factor families also regulate adipogenesis. The importance of PPARγ activity is underscored by several covalent modifications that modulate its activity and its ability to modulate adipocyte development. This review will primarily focus on the transcriptional control of adipogenesis in white fat cells and on the mechanisms involved in this fine-tuned developmental process. © 2017 American Physiological Society. Compr Physiol 7:635-674, 2017. Citing Literature Comprehensive PhysiologyBrowse other articles of this reference work:BROWSE TABLE OF CONTENTSBROWSE BY TOPICBROWSE A-Z RelatedInformation