药品
奎尼丁
药理学
医学
药物代谢
药物相互作用
洛哌丁胺
不利影响
内科学
腹泻
出处
期刊:Elsevier eBooks
[Elsevier]
日期:2009-01-01
卷期号:: 303-325
被引量:4
标识
DOI:10.1016/b978-0-12-369521-5.00012-9
摘要
This chapter explains how drug–drug interactions constitute a significant fraction of avoidable adverse drug reactions (ADRs). The frequency with which they occur depends, in part, on the number of different drugs that are used simultaneously. Although the purposeful co-administration of two drugs can be designed in such a way as to improve therapeutic outcomes or even to limit adverse effects, it is most often the case that unintended drug–drug interactions comprise a subset of ADRs. One of those is the use of drugs with narrow therapeutic ranges. The combined use of sildenafil or similar drugs for erectile dysfunction with nitroglycerin or other nitrates or nitrites for angina ultimately was discovered to cause severe, even fatal hypotension. In another instance, quinidine was shown to increase the respiratory depressant effects of loperamide in humans, and the effect was not due to the inhibition of loperamide metabolism by quinidine.
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