谷胱甘肽
氧化还原
化学
乙二醇
生物物理学
药物输送
PEG比率
还原剂
药品
组合化学
纳米技术
生物化学
药理学
酶
材料科学
有机化学
生物
经济
财务
作者
Yingfeng Tu,Fei Peng,Paul B. White,Daniela A. Wilson
标识
DOI:10.1002/anie.201703276
摘要
The development of artificial nanomotor systems that are stimuli-responsive is still posing many challenges. Herein, we demonstrate the self-assembly of a redox-responsive stomatocyte nanomotor system, which can be used for triggered drug release under biological reducing conditions. The redox sensitivity was introduced by incorporating a disulfide bridge between the hydrophilic poly(ethylene glycol) block and the hydrophobic polystyrene block. When incubated with the endogenous reducing agent glutathione at a concentration comparable to that within cells, the external PEG shells of these stimuli-responsive nanomotors are cleaved. The specific bowl-shaped stomatocytes aggregate after the treatment with glutathione, leading to the loss of motion and triggered drug release. These novel redox-responsive nanomotors can not only be used for remote transport but also for drug delivery, which is promising for future biomedical applications.
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