化学
刺猬信号通路
立体化学
体外
刺猬
水解
信号转导
生物化学
作者
Lin Zhang,Fengyang Chen,Shifang Xu,Yiping Ye,Xiaoyu Li
标识
DOI:10.1177/1934578x1400900204
摘要
Two novel steroidal aglycones, together with four known ones, were isolated from the hydrolysis extract of the CHCl 3 soluble extract of the stems of Marsdenia tenacissima. Their structures were determined on the basis of chemical evidence and extensive spectroscopic methods, including 1D and 2D NMR spectroscopy. These compounds displayed inhibition of the Hedgehog signaling pathway in vitro.
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