Dose-Response Relationships of Polycyclic Aromatic Hydrocarbons Exposure and Oxidative Damage to DNA and Lipid in Coke Oven Workers

化学 氧化应激 焦炉 泌尿系统 尿 活性氧 DNA加合物 氧化磷酸化 环境化学 DNA损伤 加合物 致癌物 苯并(a)芘 生物化学 色谱法 内科学 DNA 有机化学 焦炭 医学
作者
Dan Kuang,Wangzhen Zhang,Qifei Deng,Xiao Zhang,Kun Huang,Lei Guan,Die Hu,Tangchun Wu,Huan Guo
出处
期刊:Environmental Science & Technology [American Chemical Society]
卷期号:47 (13): 7446-7456 被引量:196
标识
DOI:10.1021/es401639x
摘要

Polycyclic aromatic hydrocarbons (PAHs) are known to induce reactive oxygen species and oxidative stress, but the dose–response relationships between exposure to PAHs and oxidative stress levels have not been established. In this study, we recruited 1333 male coke oven workers, monitored the levels of environmental PAHs, and measured internal PAH exposure biomarkers including 12 urinary PAH metabolites and plasma benzo[a]pyrene-r-7,t-8,t-9,c-10-tetrahydotetrol-albumin (BPDE-Alb) adducts, as well as the two oxidative biomarkers urinary 8-hydroxydeoxyguanosine (8-OHdG) and 8-iso-prostaglandin-F2α (8-iso-PGF2α). We found that the total concentration of urinary PAH metabolites and plasma BPDE-Alb adducts were both significantly associated with increased 8-OHdG and 8-iso-PGF2α in both smokers and nonsmokers (all p < 0.05). This exposure-response effect was also observed for most PAH metabolites (all ptrend < 0.01), except for 4-hydroxyphenanthrene and 8-OHdG (ptrend = 0.108). Furthermore, it was shown that only urinary 1-hydroxypyrene has a significant positive association with both 8-OHdG and 8-iso-PGF2α after a Bonferroni correction (p < 0.005). Our results indicated that urinary ΣOH-PAHs and plasma BPDE-Alb adducts can result in significant dose-related increases in oxidative damage to DNA and lipids. Furthermore, when a multianalyte method is unavailable, our findings demonstrate that urinary 1-hydroxypyrene is a useful biomarker for evaluating total PAHs exposure and assessing oxidative damage in coke oven workers.
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